Sanders has had a long career in film and television. He is perhaps most recognized for his work in the films The Day After Tomorrow (2004), Green Lantern (2011) and Morgan Freeman Alex Cross films. He has appeared in many other notable films, including Glory (1989), Mr. Destiny, JFK (1991), Angels in the Outfield (1994), The Big Green (1995), Daylight, Tumbleweeds (1999), Music of the Heart (1999), Half Nelson (2006), Cadillac Records (2008) and Revolutionary Road (2008).